The course launches from the first semester in 2019, and marks another step for the ANU College of Asia and the Pacific (CAP) in offering languages not widely taught at Australian universities.
ANU said its Tok Pisin teacher will be Jenny Homerang, a PhD candidate at the School of Culture, History and Language.
Homerang said its inception is a "ground-breaking achievement" for all indigenous language speakers.
"ANU is a pioneer in online language education and Tok Pisin is an important language in Papua New Guinea, because it brings the country's diverse population together. As the first institution in Australia to offer a course in this language, ANU is leading the way in teaching and valuing less commonly taught languages," she said.
Papua New Guinea is one of the world's most linguistically diverse nations with more than 800 living languages. Tok Pisin, an official language in the country along with English and Hiri Motu, is its most spoken language with around four million speakers.
Development of the Tok Pisin course has been led by the CAP Digital Education Service team, which in May was recognised at the College Forum for its outstanding efforts implementing six online language courses - Hindi, Sanskrit, Tetum, Thai, Tibetan and Vietnamese - in partnership with Open Universities Australia.
The Digital Education Service team is led by Grazia Scotellaro, who has developed language teaching in blended and online formats at ANU for more than 10 years. A former ICT lecturer at the University of Canberra, Scotellaro has broad experience working with languages and information technology in teaching.