The doctor was evacuated from Daru Island to Port Moresby on Tuesday last week but died at the weekend.
Pandemic deputy controller Dr Daoni Esorom said Daru Hospital had lost three people, all of them in their prime age, to Covid-19 in less than two weeks.
He said the deaths are most likely due to the Delta variant because it spread faster and was even deadlier for those with co-morbidities and the elderly.
Dr Esorom reiterated calls for people throughout PNG to adhere to the ‘niupela pasin', or ‘new normal' by following good hygiene and social distancing.
Meanwhile, Daru hospital still open but has scaled down its operations to emergencies and dealing with covid case.
Chief executive Dr Niko Wuatai said the hospital had requested that a clinical team from Port Moresby to be sent to Daru.
He said Daru was experiencing a third wave of the pandemic and as of Tuesday last week, the hospital had reported 89 positive cases over a period of two weeks.
"We are monitoring the situation on the island very closely given the independence celebrations and the large number of people currently on the island," Dr Wuatai said.