Speaking alongside the Canadian Prime Minister Justin Trudeau and Chinese Vice Premier Wang Yang at the Fortune 500 Global Forum in Guangzhou, China, O'Neill also promoted that key elements of the APEC 2018 agenda.
He said that logistics and security preparations were under way for Papua New Guinea to receive the 15,000 delegates and businesspeople, as well as world leaders, who would attend APEC events next year.
"The first meeting of APEC 2018 actually began today in Port Moresby with the Informal Senior Officials Meeting, and I am advised that it is proceeding well. The 2018 APEC policy agenda is also evolving and has a focus on inclusion and the digital economy, which is important for people in all countries," O'Neill said.
The digital future, and the opportunities that are presented, were beyond anything we could have imagined just a generation ago, O'Neill said.
"But access to these technologies must be inclusive. We need to make sure people right around our countries can have access to the internet, online services and banking, particularly in remote and rural areas.
"We must endeavour to leave no-one behind, to be inclusive and share opportunity, and this is the focus of APEC work on these issues. As we continue to open our economies to increased trade and people-to-people contact, we there is a lot to be gained."
In his address, and in a subsequent bilateral meeting with Vice Premier Wang, O'Neill highlighted the business opportunities that are evolving in Papua New Guinea for global investors.
"Papua New Guinea is not a country that will stand by and wait for investment to come to us. We are proactive, and engage with partners around the world to highlight the opportunity that our economy offers.
"As Chair of APEC 2018, Papua New Guinea will be inviting thousands of senior business people to take part in APEC activities throughout the year, and this will provide an opportunity for them to see first-hand the economic potential of our country."