Covid-19 infections have soared - in the past five weeks there have been about 800 cases, with Port Moresby the worst hit.
The Port Moresby General Hospital chief executive Dr Paki Molumi said the hospital was having to prioritise services, The National newspaper reported.
The Consultation Clinic is being shut for two weeks, with staff moved to other areas.
Only emergency surgery is being undertaken, while all elective surgery is on hold until further notice.
The Emergency Department will be open but the public is being encouraged to use other medical clinics.
There will be no Gynaecology Clinic, while the Antenatal Clinic will continue but with limits on bookings.
There will also be limited imaging services available, however blood services will remain at the Pathology Department.