The inaugural list compiled by the financial marketplace aims to provide investor-friendly trading for companies seeking to grow their business and increase exposure to US investors.
"We are proud to recognise the most successful OTCQX companies in our inaugural OTCQX Best 50, which are helping enhance market transparency and deliver long-term value for their shareholders," said OTC Markets Group executive vice president, corporate services Jason Paltrowitz.
The list ranks the top 50 US and international OTCQX companies based on one-year share price performance, daily dollar volume growth and performance in 2014.
Nautilus Minerals CEO Mike Johnston said the achievement reflected the good work done by the company which aimed to start production by 2018.
"We are delighted to have been named in the OTCQX Best 50," he said.
"This is a direct reflection of the hard work that our team has put in over the last year and our focus on delivering results for our shareholders.
"We remain committed to maximising shareholder value by achieving our objective of developing the world's first commercial high grade seafloor copper-gold project and launching the deep water seafloor resource production industry in 2018."
An exploration program to search for seafloor massive sulphide (SMS) systems is currently underway in the Solomon Islands, which Nautilus will target for future mining operations once its Solwara 1 project in Papua New Guinea comes online.
It also has licences in Tonga and the western Pacific.
Nautilus has contracted marine survey company Gardline CGG to undertake the exploration program, with the research ship MV Duke being deployed to the area for 43 days of service.